University of Aarhus

University of Aarhus

Aarhus University is a modern, international university founded in 1928 and consistently ranked among the world’s top 100. With five faculties spanning the full research spectrum, the university has a strong global impact. The Faculty of Health conducts education and research from biomedicine and clinical medicine to public health, forensic medicine and dentistry and oral health. With world-class facilities and a strong tradition of multidisciplinary collaboration, the faculty strives to improve health for all.

Role within GreenNanoBone

The research group from AU in collaboration of AUH and Jagielonian University, Krakow, Poland will establish a single-cell atlas of human MRONJ, highlighting the cells involved in the disease and their transcriptomic profiles. This will be achieved via:

  • Characterise cellular landscape and transcriptional states in MRONJ human samples;
  • Validate transcriptional results at the protein level aiming to identify potential therapeutic targets;
  • Establish immune, cellular and humoral responses to GreenNanoBone microgel supported by transcriptomic and proteomic profiling. Characterise microbial profile of MRONJ patients
  • Evaluation of GreenNanoBone’ ability to reduce horizontal gene transfer e.g. antibiotic resistance genes

AU will work with ASCD (Association for Study of Chronic Diseases) from Moldova on:

  • Establishing MRONJ in miniature pigs as an in vivo model and evaluate the clinical outcomes from minimally invasive surgical protocols using injectable and printable GreenNanoBone microgels

AU will also work with other partners involved in pre-clinical studies on:

  • Comparative Cross-Species Analysis of MRONJ Pathophysiology in Humans and Pigs at the Molecular Level Using OMICs Datasets.

The main goal of the above tasks is to develop a robust platform for future clinical trials using GreenNanoBone.